BDBM50595893 CHEMBL5200136

SMILES CNC(=O)c1ccc(Nc2nc(N)n(n2)C(=O)c2c(F)cc(CCNC(=O)C=C)cc2F)cc1

InChI Key InChIKey=CKKVVCFCTMZGEW-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50595893   

TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50595893(CHEMBL5200136)
Affinity DataKd:  242nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 30 mins by competitive fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50595893(CHEMBL5200136)
Affinity DataKd:  75nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 20 hrs by competitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50595893(CHEMBL5200136)
Affinity DataKd:  830nMAssay Description:Binding affinity to wild type JAK2 JH1 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 20 hrs by competitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed