BDBM50595872 CHEMBL5176104

SMILES [H][C@@]12NC(=N)N[C@]11N(C[C@H](NC(=O)c3cccc4CCCCc34)C1(O)O)C(=N)N[C@H]2CN1C(=O)CCC1=O

InChI Key InChIKey=OZAUCXKCFJDDRB-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50595872   

TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 7 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 72nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 8.07E+4nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 3.78E+3nMAssay Description:Inhibition of mouse Nav1.7 at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Rat)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of rat Nav1.7 at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 72nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.8 expressed in CHO cells at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 6.53E+4nMAssay Description:Inhibition of human Nav1.3 expressed in CHO cells at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.2 expressed in CHO cells at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells at -120 mV holding potential by automated patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595872(CHEMBL5176104)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed