BDBM50595843 CHEMBL5191508

SMILES [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(C(=O)Nc2ccc(NC[C@H]3COCCO3)cc2)c1OC

InChI Key InChIKey=ITHVYCKTQCDGNM-FIBGUPNXSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50595843   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of TYK2 in human Jurkat cells assessed as reduction in IFNalpha induced STAT3 phosphorylation incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK1 JH1 (unknown origin) using ULight -poly GT as substrate in presence of ATP incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK2 JH1 (unknown origin) using ULight -poly GT as substrate in presence of ATP incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK3 JH1 (unknown origin) using ULight -poly GT as substrate in presence of ATP incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TYK2 JH1 (unknown origin) using ULight -poly GT as substrate in presence of ATP incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of JAK2 in platelet cells (unknown origin) assessed as reduction in EPO stimulated STAT3 phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetJAK3/JAK1(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataIC50: 41nMAssay Description:Inhibition of JAK1/JAK3 in CD3+ T cells (unknown origin) assessed as reduction in IL-2 stimulated STAT5 phosphorylation incubated for 1.5 hrs by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetJAK3/JAK1(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataIC50: 33nMAssay Description:Inhibition of JAK1/JAK3 in CD3+ T cells (unknown origin) assessed as reduction in IL-6 stimulated STAT3 phosphorylation incubated for 1.5 hrs by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nanjing University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50595843(CHEMBL5191508)
Affinity DataKd: <0.0170nMAssay Description:Binding affinity to T7-tagged TYK2 JH2 (unknown origin) expressed in Escherichia coli BL21 cells incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed