BDBM50594785 CHEMBL5181008

SMILES Oc1ccc(NC2=N\C(=C/c3ccc4OCOc4c3)C(=O)N2)cc1F

InChI Key InChIKey=AKNIGLLNHUTMPO-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50594785   

TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Pig)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 550nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta using YRRAAVPPSPSLSRHSSPHQpSEDEEE as substrate incubated for 30 mins in presence of ATP by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 19nMAssay Description:Inhibition of GST-fused mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 400nMAssay Description:Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-fused mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Mouse)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 120nMAssay Description:Inhibition of mouse recombinant GST-fused CLK2 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-fused human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 23nMAssay Description:Inhibition of GST-fused human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-fused human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 170nMAssay Description:Inhibition of GST-fused human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant Pim1 expressed in Escherichia coli using histone H1 as substrate incubated for 30 mins in presence of ATP by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Manros Therapeutics & Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50594785(CHEMBL5181008)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant CK2 using RRRDDDSDDD peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed