BDBM50594749 CHEMBL5170300

SMILES COc1c(OCCCCCC(=O)NO)ccc2C3=NCCN3C(NC(=O)c3ccccc3)=Nc12

InChI Key InChIKey=MMPZSLSWQVQLJD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50594749   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory)

Curated by ChEMBL
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 50nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory)

Curated by ChEMBL
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 3nMAssay Description:Inhibition of full-length HDAC1 (unknown origin) by Color-de-Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory)

Curated by ChEMBL
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 50nMAssay Description:Inhibition of full length human recombinant HDAC1 using AcLys-Tyr-Lys(e-acetyl)-AMC as substrate incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory)

Curated by ChEMBL
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50594749(CHEMBL5170300)
Affinity DataIC50: 62nMAssay Description:Inhibition of full-length recombinant human HDAC6 using Boc-Lys(e-acetyl)-AMC as substrate incubated for 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed