BDBM50594716 CHEMBL5191956

SMILES COc1cc(NC(=O)CCCCCCC(=O)NO)ccc1Nc1nccc(n1)-c1cn(C)c2ccccc12

InChI Key InChIKey=WUPDRBBYEINKAK-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50594716   

TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 40 mins by Kinase-Glo Plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 40 mins by Kinase-Glo Plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 85nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 85nMAssay Description:Inhibition of HDAC1 in human HeLa cell nuclear extract using Bos-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of EGFR wildtype (unknown origin) incubated for 40 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of EGFR T790M (unknown origin) incubated for 40 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 40 mins in presence of ATP by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 40 mins in presence of ATP by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50594716(CHEMBL5191956)
Affinity DataIC50: 85nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed