BDBM50594494 CHEMBL5197509

SMILES COc1ccc(cc1)C(=O)O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1OC(=O)c1ccc(OC)cc1)n1cnc2c(N)ncnc12

InChI Key InChIKey=RKFOOQRRMNOARS-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50594494   

TargetP2X purinoceptor 1(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at human P2X1R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 2(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at human P2X2R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at human P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at human P2X2R/P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at human P2X4R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at human P2X7R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at human P2X7R expressed in HEK293 cells assessed as reduction in YO-PRO-1 iodide dye uptake preincubated for 30 mins followed by YO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 1(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human P2X1R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 2(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human P2X2R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human P2X2R/P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human P2X4R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594494(CHEMBL5197509)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human P2X7R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed