BDBM50594428 CHEMBL5192349

SMILES COc1ccc(CNC(=O)[C@@H]2CCC[C@@H](C2)Nc2ccc([N+]([O-])=O)c3nonc23)c(c1)C(F)(F)F

InChI Key InChIKey=BIKRZBTWBZLWMQ-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50594428   

TargetBifunctional epoxide hydrolase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50594428(CHEMBL5192349)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of C-terminal domain of human sEH-H assessed as reduction in fluorescent naphthalene aldehyde formation using PHOME as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50594428(CHEMBL5192349)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of C-terminal domain of mouse sEH-H assessed as reduction in fluorescent naphthalene aldehyde formation using PHOME as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50594428(CHEMBL5192349)
Affinity DataKd:  6nMAssay Description:Binding affinity to NanoLuc-fused human sEH ( 1 to 555 residues) expressed in HEK293T cells incubated for 5 hrs by NanoBRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed