BDBM50594147 CHEMBL5203091::US12390472, Example 68

SMILES CCN(C1CCC(F)(F)CC1)c1cc(O[C@H]2C[C@@H](C2)N2CCCCC2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C

InChI Key InChIKey=QORWWAYMVGOJGG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50594147   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
Targety641n(Mouse)
Evopoint Biosciences Co.

US Patent
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
In Depth
Date in BDB:
11/25/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Evopoint Biosciences Co.

US Patent
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2025
Entry Details
Go to US Patent