BDBM50594134 CHEMBL5187783

SMILES CCN(C1CCC(CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(OCCOC)cc1

InChI Key InChIKey=YAYHRYAVXZWUIJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50594134   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594134(CHEMBL5187783)
Affinity DataIC50: 5nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594134(CHEMBL5187783)
Affinity DataIC50: 77nMAssay Description:Inhibition of EZH2 (unknown origin) assessed as reduction in H3K27me3 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed