BDBM50594106 CHEMBL5202637

SMILES COc1cc2c(NC3CCN(Cc4ccccc4)CC3)nc(NCCCN(C)C)nc2cc1OCc1ccccc1

InChI Key InChIKey=CLMKFAVBRRFUGX-UHFFFAOYSA-N

Data  2 KI  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50594106   

TargetREST corepressor 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataKd:  67nMAssay Description:Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DOTL1 (unknown origin) using [3H]SAM and HeLa oligo nucleosomes as substrates incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SETD8 (unknown origin) using [3H]SAM and HeLa nucleosomes as substrates incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of EZH2 (unknown origin) using [3H]SAM and chicken core histone as substrates incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PRMT1 (unknown origin) using [3H]SAM and chicken histone 4 as substrates incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MAO-A using p-tyramine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MAO-B using p-tyramine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetREST corepressor 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataKi:  108nMAssay Description:Inhibition of human LSD1/CoREST using histone H3 peptide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50594106(CHEMBL5202637)
Affinity DataKi:  3.94E+4nMAssay Description:Inhibition of G9a (unknown origin) assessed as reduction in substrate methylation using histone H3 and SAM as substrate measured after 15 to 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed