BDBM50593495 CHEMBL5196156

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1nc(C)ns1)C2NC1=NC2C=CC=C(C2=N1)c1ccc(F)c(F)c1F

InChI Key InChIKey=VOROBJLBTJUGCC-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50593495   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Indian Institute of Technology (B.H.U.)

Curated by ChEMBL

LigandBDBM50593495(CHEMBL5196156)Copy SMILESCopy InChI

Affinity DataIC50: 4.5nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levelsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2023
Entry Details
Copy Entry DOIPubMed
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TargetPresenilin-1(Human)
Indian Institute of Technology (B.H.U.)

Curated by ChEMBL

LigandBDBM50593495(CHEMBL5196156)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in free Abeta42 levelsMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL