BDBM50593362 CHEMBL5174358

SMILES Fc1ccc(cc1)C1=NN(C(C1)c1ccco1)C(=O)COc1ccc(\C=C2\SC(=O)NC2=O)cc1

InChI Key InChIKey=KXAPDKXGXJJUQC-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50593362   

TargetHistone deacetylase 4(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50593362(CHEMBL5174358)
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant human N-terminal His6-SUMO-tagged C-terminal SII-tagged HDAC4 expressed in Escherichia coli (BL21) DE3 pLysS cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50593362(CHEMBL5174358)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human N-terminal His6-SUMO-tagged C-terminal SII-tagged HDAC8 expressed in Escherichia coli (BL21) DE3 pLysS cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50593362(CHEMBL5174358)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human C-terminal His6-FLAG-tagged HDAC1 (1 to end residues) expressed in sf9 insect cells using Boc-Lys(acetyl)-AMC as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50593362(CHEMBL5174358)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human HDAC2 Boc-Lys(acetyl)-AMC as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50593362(CHEMBL5174358)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50593362(CHEMBL5174358)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(acetyl)-AMC as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50593362(CHEMBL5174358)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected sf9 insect cells using BocLys(tri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bharati Vidyapeeth'S College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50593362(CHEMBL5174358)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human VEGFR2 in HUVEC cells assessed as reduction in VEGFR2 phosphorylation incubated for 30 mins by anti-phospho VEGF Tyr 1175 antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed