BDBM50593308 CHEMBL5205935

SMILES CN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3ccc4oc(=O)[nH]c4c3)n2)cn1

InChI Key InChIKey=VRHMZZOLTHXZAU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50593308   

TargetJAK3/JAK1(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593308(CHEMBL5205935)
Affinity DataIC50: 20nMAssay Description:Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593308(CHEMBL5205935)
Affinity DataIC50: 84nMAssay Description:Inhibition of JAK2 signaling pathway in human CHEP cells assessed as inhibition of EPO-induced cell survival preincubated for 1 hr followed by EPO ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593308(CHEMBL5205935)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in absence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593308(CHEMBL5205935)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed