BDBM50593225 CHEMBL5193772

SMILES OC1CCN(Cc2ccc(cc2)C#Cc2cc(F)c3cn(nc3c2)C(C(=O)Nc2nccs2)c2ncn3CCCc23)CC1

InChI Key InChIKey=BZSGFJXBDPQPNT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50593225   

TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593225(CHEMBL5193772)
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593225(CHEMBL5193772)
Affinity DataIC50: 106nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593225(CHEMBL5193772)
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells incubated for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed