BDBM50593065 CHEMBL5186605

SMILES Fc1cc(F)cc(NC(=O)CCc2cccc(c2)-c2cnc3[nH]ccc3c2)c1

InChI Key InChIKey=ZEEOXLPFSJJQMJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50593065   

TargetCyclin-dependent kinase 8(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50593065(CHEMBL5186605)
Affinity DataIC50: 63nMAssay Description:Inhibition of CDK8 (unknown origin) incubated in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50593065(CHEMBL5186605)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CDK8 in human HCT-116 cells transfected with TOPFlash luciferase reporter plasmid assessed as reduction in TCF/LEF transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed