BDBM50593023 CHEMBL5183504

SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc(F)c1F)B(O)O

InChI Key InChIKey=JBYSVYLKZYAPFV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50593023   

TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50593023(CHEMBL5183504)
Affinity DataIC50: 49nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50593023(CHEMBL5183504)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed