BDBM50592194 CHEMBL5195355

SMILES Cc1cccc2[nH]c(nc12)-c1cncc(-c2cc(F)cc(c2)C#N)c1N1CC[C@H](N)C1

InChI Key InChIKey=UTCVPVMMHVQGPZ-UHFFFAOYSA-N

Data  7 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50592194   

TargetSomatostatin receptor type 5(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50:  0.370nMAssay Description:Agonist activity at human SST5 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 5(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at human SST5 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 1(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human SST1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 1(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human SST1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human SST2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 3(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human SST3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 4(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human SST4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 2(Rat)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at rat SST5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 2(Rat)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at rat SST5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin) preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592194(CHEMBL5195355)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed