BDBM50592050 CHEMBL5180577

SMILES CN1CCN(CC1)c1ccc(Nc2nc(NC(C)=O)c(s2)C(=O)c2c(Cl)cccc2Cl)cc1

InChI Key InChIKey=ZQXIMAIEMUSYSB-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50592050   

TargetCyclin-dependent kinase 11A(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50592050(CHEMBL5180577)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to wild type human partial length CDK11A (D391 to K730 residues) expressed in bacterial expression system assessed as dissociation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 11A(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50592050(CHEMBL5180577)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of N-terminus or C-terminus NLuc fused CDK11A (unknown origin) transfected in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50592050(CHEMBL5180577)
Affinity DataIC50: 672nMAssay Description:Inhibition of human recombinant full length GST-tagged CDK4/Cyclin D1 expressed in Baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50592050(CHEMBL5180577)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of human recombinant full length GST-tagged CDK6/Cyclin D1 expressed in Baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50592050(CHEMBL5180577)
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/Cyclin T1 expressed in Baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed