BDBM50591901 CHEMBL5172580

SMILES FC(F)(F)c1cc(NC(=O)[C@@H]2C[C@@H](CN2)n2cc(nn2)-c2ccc3nc(NC(=O)C4CC4)sc3n2)ccc1Cl

InChI Key InChIKey=TYVQJCSBHJOJCN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50591901   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50591901(CHEMBL5172580)
Affinity DataIC50: 25nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591901(CHEMBL5172580)
Affinity DataIC50: 110nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed