BDBM50591898 CHEMBL5170705

SMILES CC(C)(C)OC(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)n1cc(nn1)-c1ccc2nc(N)sc2n1

InChI Key InChIKey=AZCFXTPLBWULJY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50591898   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50591898(CHEMBL5170705)
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591898(CHEMBL5170705)
Affinity DataIC50: 667nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed