BDBM50591885 CHEMBL5177033

SMILES CC(C)(C)OC(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)n1cc(nn1)-c1ccc2c(N)n[nH]c2c1

InChI Key InChIKey=OHHSWQIUXWNAGL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50591885   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50591885(CHEMBL5177033)
Affinity DataIC50: 22nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591885(CHEMBL5177033)
Affinity DataIC50: 150nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed