BDBM50591533 CHEMBL4449485

SMILES CC(C)(C)CNC(=O)Nc1ccc2N(Cc3ccc(F)cc3)CCc2c1

InChI Key InChIKey=WPKIQACLHOSWIL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50591533   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50591533(CHEMBL4449485)
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50591533(CHEMBL4449485)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50591533(CHEMBL4449485)
Affinity DataIC50: 100nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50591533(CHEMBL4449485)
Affinity DataIC50: 180nMAssay Description:Inhibition of 5-LOX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed