BDBM50591337 CHEMBL5192445::US20240182406, Example 10

SMILES FC(F)(F)C(=O)N1CCC(CC1)NC(=O)NC12CC3CC(Cl)(CC(C1)c1ccccc31)C2

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50591337   

TargetBifunctional epoxide hydrolase 2(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50591337(CHEMBL5192445 | US20240182406, Example 10)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human sEH using Nonfluorescent Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50591337(CHEMBL5192445 | US20240182406, Example 10)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of mouse sEH in using using Nonfluorescent Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50591337(CHEMBL5192445 | US20240182406, Example 10)
Affinity DataIC50: 630nMAssay Description:Inhibition of human recombinant CYP2C19 using 3-cyano-7-ethoxycoumarin as a substrate preincubated for 5 mins followed by substrate addition by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpoxide hydrolase 1(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50591337(CHEMBL5192445 | US20240182406, Example 10)
Affinity DataIC50: 0.400nMAssay Description:The fluorescent assay was used with purified recombinant human or mouse sEH proteins. The enzymes were incubated at 30° C. with the inhibitors ([I]fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
Go to US Patent