BDBM50591317 CHEMBL5191783

SMILES C[C@H]1C[C@H](CCO1)N1C(=O)C[C@](C)(NC1=N)c1cccc(Nc2ccc(nc2)C2CC2)c1Cl

InChI Key InChIKey=NRQARCCHBBGTDO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50591317   

TargetPlasmepsin X(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 7nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPlasmepsin IX(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 250nMAssay Description:Inhibition of Plasmodium falciparum PMIX by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCathepsin D(Human)
Ucb

Curated by ChEMBL
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 64nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRenin(Human)
Ucb

Curated by ChEMBL
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 180nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of hERG cardiac ion channel by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of NaV1.5 (unknown origin) cardiac ion channel by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of NaV1.8 (unknown origin) cardiac ion channel by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin) cardiac ion channel by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Kv1.5 (unknown origin) by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of Kv4.3 (unknown origin) by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed