BDBM50591024 CHEMBL5188048

SMILES c1ccc(cc1)N(CC#Cc2cccnn2)C(=O)Cc3ccc(cc3C(F)(F)F)C(F)(F)F

InChI Key InChIKey=SCSRPWBBDHKGCX-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50591024   

TargetDNA polymerase theta(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591024(CHEMBL5188048)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)