BDBM50590799 CHEMBL5179132

SMILES Fc1cccc(CN(C2CCN(CCc3ccccc3)CC2)C(=O)c2ccco2)c1

InChI Key InChIKey=KFNBRURSYGJOHJ-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50590799   

TargetMu-type opioid receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM50590799(CHEMBL5179132)
Affinity DataEC50:  49nMAssay Description:Partial agonist activity at human MOR expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM50590799(CHEMBL5179132)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM50590799(CHEMBL5179132)
Affinity DataKi:  36nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590799(CHEMBL5179132)
Affinity DataKi:  36nMAssay Description:Antagonist activity at sigma1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM50590799(CHEMBL5179132)
Affinity DataKi:  448nMAssay Description:Binding affinity to sigma2 receptor (unknown origin) measured by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed