BDBM50590546 CHEMBL5177793

SMILES Cc1ccc2[nH]ncc2c1-c1c(Cl)cc2c(nc(OCCCN3CCOCC3)nc2c1F)N1CCC2(CN(C2)C(=O)C=C)CC1

InChI Key InChIKey=ZUHLKLKTXZSASX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50590546   

TargetGTPase KRas(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50590546(CHEMBL5177793)
Affinity DataIC50: 650nMAssay Description:Inhibition of biotinylated Avi-tagged GDP-bound KRAS G12C mutant (1 to 185 residues) (unknown origin) assessed as inhibition of KRAS G12C mutant/SOS/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed