BDBM50590456 CHEMBL5188909

SMILES CC(C)n1cnc2c(NCc3nc4ccc(F)c(F)c4[nH]3)nc(nc12)N1CCCC[C@H]1CCO

InChI Key InChIKey=KULPPFCRBINTBS-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50590456   

TargetCyclin-dependent kinase 12(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 491nMAssay Description:Inhibition of CDK12 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 9.09E+3nMAssay Description:Inhibition of CDK9 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK7 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of CDK2 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 31nMAssay Description:Inhibition of GST-tagged recombinant human CDK12 (696 to 1082 residues) expressed in Insect cell in presence of ATP by Km ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 491nMAssay Description:Inhibition of GST-tagged recombinant human CDK12 (696 to 1082 residues) expressed in Insect cell in presence of ATP by high ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 9.09E+3nMAssay Description:Inhibition of full length recombinant human CDK9 expressed in Insect cell in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of full length recombinant human CDK7 expressed in Insect cell in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of full length recombinant human CDK2 expressed in Insect cell in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590456(CHEMBL5188909)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of full length recombinant human CDK1 expressed in Insect cell in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed