BDBM50590376 CHEMBL5193486

SMILES CN(C)C1CCC(CC1)C1(C)Oc2c(O1)c(C)c(cc2Cl)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=SSDRNUPMYCFXGM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50590376   

TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590376(CHEMBL5193486)
Affinity DataIC50: 16nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590376(CHEMBL5193486)
Affinity DataIC50: 23nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590376(CHEMBL5193486)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of EZH2 in human HCT-116 cells assessed as inhibition of H3K27me3 incubated for 3 days by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed