BDBM50590367 CHEMBL384575

SMILES CO[C@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1

InChI Key InChIKey=XKFTZKGMDDZMJI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50590367   

TargetTyrosine-protein kinase ABL1(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590367(CHEMBL384575)
Affinity DataIC50: 25nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590367(CHEMBL384575)
Affinity DataIC50: 47nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590367(CHEMBL384575)
Affinity DataIC50: 25nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590367(CHEMBL384575)
Affinity DataIC50: 31nMAssay Description:Inhibition of TrKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590367(CHEMBL384575)
Affinity DataIC50: 31nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed