BDBM50590283 CHEMBL5169766::US20230303547, Reference Example D::US20240335427, Compound 23

SMILES O=C(Nc1ncc(s1)-c1ccccc1)[C@H]1CCN(C1)C#N

InChI Key InChIKey=DPOQOSJMDTZFOR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50590283   

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D...)
Affinity DataIC50: 310nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 µM for a final concentration of 100 µM) in 50% DMSO in a 96-well polypropylen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D...)
Affinity DataIC50: 580nMAssay Description:Inhibition of GST-tagged recombinant UCHL1 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L3(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D...)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged recombinant UCHL3 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D...)
Affinity DataIC50: 550nMAssay Description:Inhibition of FLAG-tagged UCHL1 (unknown origin) expressed in CAL-51 cells using HA-Ub-VME as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Mission Therapeutics

US Patent
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D...)
Affinity DataIC50: 310nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 µM for a final concentration of 100 µM) in 50% DMSO in a 96-well polypropylen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D...)
Affinity DataIC50: 73nMAssay Description:In vitro JOSD1 activity assay was carried out with Ubiquitin-AMC assay. The Ubiquitin-AMC assay was carried out as previously described (Wernig, et a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetJosephin-1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D...)
Affinity DataIC50: 660nMAssay Description:In vitro JOSD1 activity assay was carried out with Ubiquitin-AMC assay. The Ubiquitin-AMC assay was carried out as previously described (Wernig, et a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent