BDBM50589769 CHEMBL5174111

SMILES c1cc(cnc1)C(=O)N2CCN([C@@H](C2)C(=O)NCc3cccs3)c4ccc(c(c4)Cl)Cl

InChI Key InChIKey=XEFYJHCPILXFKJ-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50589769   

TargetCaspase-3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human caspase-3 using Ac-Asp-Glu-Val-Asp-pNA as substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCathepsin F(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin F using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin K using Ac-LR-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Cathepsin B using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 400nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 30 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 400nMAssay Description:Inhibition of SARS-CoV-2 Main protease using as Dabcyl-KNSTLQSGLRKE-Edans substrate preincubated for 10 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50589769(CHEMBL5174111)
Affinity DataIC50: 400nMAssay Description:Inhibition of SARS CoV-2 MPro using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 10 mins followed by substrate addition measured for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed