BDBM50589660 CHEMBL5193071

SMILES CC(C)Nc1ncc(-c2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)c(=O)[nH]1

InChI Key InChIKey=UREZAFQRYNPCHA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50589660   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589660(CHEMBL5193071)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589660(CHEMBL5193071)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of His-tagged recombinant human FLT3 (564 to 958 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589660(CHEMBL5193071)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha (unknown origin) (550 to 1089 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589660(CHEMBL5193071)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRbeta (unknown origin) (557 to 1106 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589660(CHEMBL5193071)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589660(CHEMBL5193071)
Affinity DataIC50: 8nMAssay Description:Inhibition of CSF1R in CSF1-stimulated human THP-1 cells assessed as inhibition of CSF1R phosphorylation measured by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed