BDBM50588765 CHEMBL5184953

SMILES CNC(=O)c1cc(C(F)F)c(F)c(c1)-c1cnc2cc(-c3cnn(C)c3)c(O[C@H]3CCOC3)nn12

InChI Key InChIKey=VSDZEHDPNRWKLG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50588765   

TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588765(CHEMBL5184953)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 residues) expressed in an Sf9 infected baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588765(CHEMBL5184953)
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588765(CHEMBL5184953)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human FGFR3 V555M mutant using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Mouse)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588765(CHEMBL5184953)
Affinity DataIC50: 13nMAssay Description:Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588765(CHEMBL5184953)
Affinity DataIC50: 98nMAssay Description:Inhibition of wild type partial length human FLT3 (V592 to Y969 residues) expressed in bacterial expression system using Ulight-p70S6K peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588765(CHEMBL5184953)
Affinity DataIC50: 443nMAssay Description:Inhibition of wild type partial length human TRKA (G475 to G790 residues) expressed in mammalian expression system using Ulight-p70S6K peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588765(CHEMBL5184953)
Affinity DataIC50: 619nMAssay Description:Inhibition of wild type partial length human KIT (I571 to D952 residues) expressed in bacterial expression system using Ulight-p70S6K peptide substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50588765(CHEMBL5184953)
Affinity DataIC50: 800nMAssay Description:Inhibition of wild type partial length human PDGFRbeta (V582 to Y1009 residues) expressed in bacterial expression system using Ulight-p70S6K peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed