BDBM50588683 CHEMBL5187433

SMILES CN(C)c1ccc(cc1)C(=O)N(Cc2ccc(cc2F)C(=O)NO)CC(=O)NCc3ccccc3

InChI Key InChIKey=GBIQEYYBFBGNOZ-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50588683   

TargetHistone deacetylase 1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50588683(CHEMBL5187433)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Z-Lys(Ac)-AMC as fluorogenic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50588683(CHEMBL5187433)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using Z-Lys(Ac)-AMC as fluorogenic sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50588683(CHEMBL5187433)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using Z-Lys(Ac)-AMC as fluorogenic sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50588683(CHEMBL5187433)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 (1 to 488 residues) expressed in Sf9 insect cells using Z-Lys(Ac)-AMC as fluorogenic sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM50588683(CHEMBL5187433)
Affinity DataIC50: 21nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50588683(CHEMBL5187433)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf9 insect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed