BDBM50588242 CHEMBL5192885

SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=AKZKUGUQZMUCJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50588242   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588242(CHEMBL5192885)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588242(CHEMBL5192885)
Affinity DataIC50: 35nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50588242(CHEMBL5192885)
Affinity DataIC50: 60nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed