BDBM50588040 CHEMBL5196736

SMILES Fc1cc(Cl)cc(N[C@H](C2CC2)C(=O)N[C@@H]2CCCN(C2)c2ncnc3[nH]ncc23)c1

InChI Key InChIKey=IVUHUFVVODTZOQ-UHFFFAOYSA-N

Data  1 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50588040   

TargetTyrosine-protein kinase BTK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50588040(CHEMBL5196736)
Affinity DataIC50: 11nMAssay Description:Inhibition of BTK (unknown origin) incubated 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50588040(CHEMBL5196736)
Affinity DataKd:  9nMAssay Description:Binding affinity to human full length BTK C481S mutation (M1 to S659 residues ) expressed in mammalian expression system assessed dissociation consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50588040(CHEMBL5196736)
Affinity DataKd:  50nMAssay Description:Binding affinity to human partial length TEC (L341 to D620 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50588040(CHEMBL5196736)
Affinity DataKd:  190nMAssay Description:Binding affinity to human partial length ITK (R335 to L620 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50588040(CHEMBL5196736)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to human partial length TXK (L238 to W527 residues ) expressed in bacterial expression system assessed dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50588040(CHEMBL5196736)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human full length BMX (M1 to H675 residues ) expressed in bacterial expression system assessed dissociation constant by Kinomesca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed