BDBM50588000 CHEMBL4875115

SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCN(CC1)C(=O)CNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

InChI Key InChIKey=UMEMOEKJTJMMJN-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50588000   

TargetALK tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50588000(CHEMBL4875115)
Affinity DataIC50: 1.36E+4nMAssay Description:Binding affinity to ALK (unknown origin) using TK as substrate incubated for 1 hr in presence of ATP by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEchinoderm microtubule-associated protein-like 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50588000(CHEMBL4875115)
Affinity DataEC50:  27nMAssay Description:Protac activity at CRBN/EML4-ALK in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation incubated for 16 hrs by Wester...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed