BDBM50587940 CHEMBL5171372

SMILES COc1cc(cc(OC)c1OC)C(=O)c1csc(n1)-c1ccc(NC(=O)CCCCC(=O)Nc2ccccc2N)cc1

InChI Key InChIKey=ICNXQGIQKLFLOX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50587940   

TargetHistone deacetylase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50587940(CHEMBL5171372)
Affinity DataIC50: 8.12E+3nMAssay Description:Inhibition of full length recombinant human HDAC1 (1 to 482 residues) expressed in Baculovirus system using Ac-Leu-Gly-Lys (Ac)-AMC as substrate pret...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50587940(CHEMBL5171372)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin) using Ac-Leu-Gly-Lys (Ac)-AMC as substrate pretreated for 5 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50587940(CHEMBL5171372)
Affinity DataIC50: 3.64E+4nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Baculovirus infected Sf9 cells using Ac-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50587940(CHEMBL5171372)
Affinity DataIC50: 5.83E+4nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC7 (501 to 952 residues) expressed in Baculovirus system using Ac-Leu-Gly-Lys (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50587940(CHEMBL5171372)
Affinity DataIC50: 8.74E+3nMAssay Description:Inhibition of full length C-terminal his-tagged human recombinant HDAC8 (142 to 143 residues) expressed in baculovirus in Sf9 insect cells using Ac-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed