BDBM50587882 CHEMBL5190467::WO2020/142729, Example 28

SMILES Cc1nc(N2C[C@@H](CC(=O)Nc3ccncc3)C[C@H]2C(O)=O)c2oc3ccccc3c2n1

InChI Key InChIKey=YCQPLARUWCECQR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50587882   

TargetCyclic GMP-AMP synthase(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587882(CHEMBL5190467 | WO2020/142729, Example 28)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of cGAS expressed in human THP-1 cells assessed as reduction of IFN-beta expression by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587882(CHEMBL5190467 | WO2020/142729, Example 28)
Affinity DataIC50: 630nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587882(CHEMBL5190467 | WO2020/142729, Example 28)
Affinity DataIC50: 630nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587882(CHEMBL5190467 | WO2020/142729, Example 28)
Affinity DataIC50: 7.17E+4nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent