BDBM50587878 CHEMBL5175791

SMILES CCN(C)CC(=O)NC12CCC(Cn3nc(C)c4CN(CCc34)c3cc(C)nc4n(C)ncc34)(CC1)CC2

InChI Key InChIKey=DPBHELMHVHQEEY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50587878   

TargetToll-like receptor 7(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587878(CHEMBL5175791)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at TLR7 in human PBMC incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587878(CHEMBL5175791)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at TLR8 in human PBMC incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetToll-like receptor 9(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587878(CHEMBL5175791)
Affinity DataIC50: 260nMAssay Description:Antagonist activity at TLR9 in human PBMC incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetToll-like receptor 7(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587878(CHEMBL5175791)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at TLR7 in human PBMC cells assessed as reduction in IFN alpha measured after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587878(CHEMBL5175791)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at TLR8 in human PBMC cells expressed in Drosophila S2 expression system assessed as reduction in IL-6 level measured after 20 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetToll-like receptor 9(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587878(CHEMBL5175791)
Affinity DataIC50: 260nMAssay Description:Antagonist activity at TLR9 in human PBMC cells assessed as reduction in IFN alpha measured after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed