BDBM50587875 CHEMBL5197568

SMILES C[C@@H]1CN(C[C@@H](O1)C(=O)NC1CCN(C)CC1)c1ccc(C#N)n2ncc(F)c12

InChI Key InChIKey=BDIGEVODPAZVFS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50587875   

TargetToll-like receptor 7(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587875(CHEMBL5197568)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at R848 stimulated TRL7 in HEK-Blue hTLR7 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587875(CHEMBL5197568)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at R848 stimulated TRL8 in HEK-Blue hTLR8 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetToll-like receptor 9(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50587875(CHEMBL5197568)
Affinity DataIC50: 1.40E+4nMAssay Description:Antagonist activity at R848 stimulated TRL9 in HEK-Blue hTLR9 cells assessed as inhibition of NF kappa B/Ap-1 activation measured after 20 hrs by SEA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed