BDBM50587598 CHEMBL5074957::US11661419, Example 46::US20230280220, Example 46
SMILES [H][C@@]12C[C@]1(C)Cc1[nH]nc(c1C2)-c1nc2cc(N(C)C(=O)[C@H](C)N3CCOCC3)c(C)c(F)c2[nH]1
InChI Key InChIKey=YJXJVYHWTNXNHX-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50587598
Affinity DataIC50: 6nMAssay Description:Inhibition of ITK (unknown origin) using BTK peptide as substrate preincubated for 30 mins followed by addition of substrate and measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of IL-2 in CD3/CD28 activated human CD4+ve Th cells preincubated for 15 mins followed by addition of immuno-cult and measured after 24 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:ITK activity was determined by measuring the effect of a test compound in an ITK enzyme assay. 1.0 M HEPES Buffer pH 7.5 solution was prepared as fol...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:1.0M HEPES Buffer pH 7.5 solution was prepared as follows: 238.3 g HEPES free acid (Sigma) and 800 mL of water were combined, and the mixture was sti...More data for this Ligand-Target Pair