BDBM50587266 CHEMBL5086690

SMILES ONC(=O)c1ccc(CN2CCc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc23)cc1

InChI Key InChIKey=VPSBSBHMOGBXFD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50587266   

TargetHistone deacetylase 8(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50587266(CHEMBL5086690)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of recombinant C-terminal His-fusion tagged/N-terminal Strep2 tagged human HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50587266(CHEMBL5086690)
Affinity DataIC50: 250nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 insect cells using RHK-K(Ac)-AMC as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed