BDBM50587254 CHEMBL5069833

SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1cccc(CCC(=O)Nc2ccccc2N)c1

InChI Key InChIKey=VXAGNKFGIRXLSP-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50587254   

TargetBromodomain-containing protein 4(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587254(CHEMBL5069833)
Affinity DataKd:  6.92E+3nMAssay Description:Binding affinity to human BRD4 domain 1 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587254(CHEMBL5069833)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant HDAC6 assessed as fluorescence using fluorogenic substrate ZMAL incubated for 90 min by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587254(CHEMBL5069833)
Affinity DataIC50: 2.82E+4nMAssay Description:Inhibition of human recombinant HDAC1 assessed as fluorescence using fluorogenic substrate ZMAL incubated for 90 min by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed