BDBM50587253 CHEMBL5094765

SMILES CCc1c(c([nH]c1C(=O)Nc2cccc(c2)CCC(=O)NO)C)C(=O)C

InChI Key InChIKey=JZECKTZTLWIBPJ-UHFFFAOYSA-N

Data  2 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50587253   

TargetBromodomain-containing protein 4(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587253(CHEMBL5094765)
Affinity DataKd:  1.15E+4nMAssay Description:Binding affinity to human BRD4 domain 1 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 6(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587253(CHEMBL5094765)
Affinity DataIC50: 658nMAssay Description:Inhibition of human recombinant HDAC6 assessed as fluorescence using fluorogenic substrate ZMAL incubated for 90 min by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587253(CHEMBL5094765)
Affinity DataIC50: 900nMAssay Description:Inhibition of human recombinant HDAC1 assessed as fluorescence using fluorogenic substrate ZMAL incubated for 90 min by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed