BDBM50587249 CHEMBL5094795

SMILES CCc1c([nH]c(C)c1C(C)=O)C(=O)Nc1cccc(\C=C\C(=O)NO)c1

InChI Key InChIKey=GVORXNGLOKKWIC-UHFFFAOYSA-N

Data  4 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50587249   

TargetBromodomain-containing protein 3(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human BRD3 domain 1 assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human BRD2 domain 2 assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataKd:  7.70E+3nMAssay Description:Binding affinity to human BRD2 domain 1 assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataKd:  4.50E+3nMAssay Description:Binding affinity to human BRD4 domain 1 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataIC50: 45nMAssay Description:Inhibition of human recombinant HDAC6 assessed as fluorescence using fluorogenic substrate ZMAL incubated for 90 min by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataIC50: 125nMAssay Description:Inhibition of human recombinant HDAC1 assessed as fluorescence using fluorogenic substrate ZMAL incubated for 90 min by microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human BRD3 domain 2 assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 7(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human BRD7 assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataIC50: 168nMAssay Description:Inhibition of human HDAC2 assessed as target activity using fluorogenic substrate ZMAL for 90 min by microplate reader at 355nmMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50587249(CHEMBL5094795)
Affinity DataIC50: 149nMAssay Description:Inhibition of human HDAC3 assessed as target activity using fluorogenic substrate ZMAL for 90 min by microplate reader at 355nmMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed