BDBM50587186 CHEMBL5088034

SMILES ONC(=O)CCCSC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc2ccccc12

InChI Key InChIKey=ZPFRKIBHYHVPPO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50587186   

TargetHistone deacetylase 6(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 69nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 72nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 150nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 200nMAssay Description:Inhibition of human HDAC4 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 200nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as fluorogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 200nMAssay Description:Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 200nMAssay Description:Inhibition of human HDAC5 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 200nMAssay Description:Inhibition of full length human HDAC2 using Boc-Lys(acetyl)-AMC as fluorogenic substrate measured after 1 hr by flourescence plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50587186(CHEMBL5088034)
Affinity DataIC50: 200nMAssay Description:Inhibition of human N-terminal GST tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(acetyl)-AMC as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed