BDBM50586752 CHEMBL5089310

SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2ccc3n(C(C)C)c(Cc4ccc(cc4)C(F)(F)F)cc3c2)cc1

InChI Key InChIKey=RGOVUCHNVVJJKB-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50586752   

TargetNuclear receptor ROR-gamma(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586752(CHEMBL5089310)
Affinity DataEC50:  150nMAssay Description:Antagonist activity at N-terminal GST tagged human RORgamma LBD using fluorescein-D22 as coactivator incubated for 60 mins by Lanthascreen TR-FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586752(CHEMBL5089310)
Affinity DataEC50:  109nMAssay Description:Antagonist activity at human RORgamma in cytostim stimulated human PBMC cells assessed as decrease in differentiation of TH17 cells by measuring IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed